Decoding the Language of Delivery with Directed Evolution & AI-Guided Protein Design
Time: 11:30 am
day: Day Two
Details:
- Introduction of the FORGETM platform which leverages unbiased directed evolution and AI-guided protein design to discover novel ligands for tissue-selective delivery
- Application of FORGETM in the discovery of ligands targeting skeletal muscle, adipose tissue, and CNS with in vivo proof-of-concept delivering various oligonucleotide payloads
- Next research frontier focused on subcellular delivery by utilizing AI to design multi-functional delivery proteins capable of tissue selectivity and subcellular localization
