Harnessing Computational Tools for Re-Targeting of Virus-Like Particles (VLP) Delivering RNA Medicines
Time: 11:00 am
day: Day Two
Details:
- Viral-like particles (VLPs) are important therapeutic delivery tools for DNA and RNA, with innate tropism
- Using combinations of 3d structure prediction and physics models to facilitate reprogramming the molecular affinities of VLP binding proteins, in order to facilitate targeted delivery beyond the wild type tissue type targets
- Novel binding proteins are designed for a variety of related viral vectors and the results are validated experimentally
