Sizhen Li

Company: Sanofi

Job title: Computational Scientist Lead

Seminars:

Leveraging a Small Language Model to Achieve Full-Length mRNA Analysis with Improved Prediction of Stability & Translation Efficiency 12:25 pm

CodonBERT is pre-trained on 10 million mRNA sequences to capture codon dependencies and interactions across different species mRNA-LM extends CodonBERT from the CDS to full-length mRNA by integrating two pre-trained BERT models on UTR regions Both CodonBERT and mRNA-LM show significant improvements in predicting mRNA properties compared to existing methodsRead more

day: Day One

Panel Discussion: Driving Safer Delivery of RNA Therapeutics & Vaccines by Leveraging Computational Tools with Better Prediction of Targeting & Specificity 12:00 pm

How to optimize machine learning algorithms for better prediction of LNP targeting and specificity How to develop computational tools for incorporating addition of targeting moieties on LNPs How can AI/ML indicate impact of lipid properties and RNA modifications on LNP performance? Uncover computational strategies for delivery vehicles beyond LNPs for selective and precise delivery of…Read more

day: Day Two