8:00 am Check-In & Morning Coffee
9 am – 12 pm | WORKSHOP A
Unlocking RNA Mechanistic Biology to Generate & Optimize Quality Datasets & Advance Computational Tools for Better RNA Discovery
Synopsis
While there has been a remarkable boom in the application of AI/ML and computational tools in protein and small molecule drug discovery, the RNA therapeutics field is striving to keep up pace with its own limitations in tailored computational tools, and presents unique challenges. Understanding RNA biological mechanisms and its structure-function relationship is crucial to optimize and inform quality datasets for data generation and enhance novel computational tools to aid the RNA discovery process. This workshop will be led by key thought leaders to elevate your insights into RNA structure discovery tools and explore interdisciplinary perspectives to ultimately advance and facilitate computational tools for RNA therapeutic discovery.
Topics include:
- What are the key principles of computational models and experimental dataset generation to be applied to RNA therapeutics?
- What are the biological mechanisms that underly RNA function and must be understood to inform datasets training?
- How to leverage knowledge of the RNA structure-function relationship to develop and derive new computational model systems?
1pm – 4 pm | WORKSHOP B
Computational Strategies Beyond Tradtional LNPs to Enhance Extrahepatic RNA Delivery & Achieve Targeted Therapeutic Benefit
Synopsis
Non-traditional delivery carriers, outside the realm of LNPs, are showing great potential to overcome patent challenges and improved targeting beyond the liver with reduced immunogencity. There are now novel methods and computational tools to identify optimal candidates for adeno-associated virus (AAV) delivery and peptide conjugation pairs. This workshop will advance your insights into optimal candidate selection for RNA delivery depending on the therapeutic indication, by harnessing computational power.
Topics include:
- What computational models can be harnessed to facilitate the identification of optimal candidates for peptide-based conjugates to reduce quantity of binding assays needed and advance drug delivery screening?
- How to harness computational design and modeling techniques for screening and optimization of AAV delivery for RNAs?
- How to optimize algorithm parameters for computational strategies to minimize immunogenicity response and tailor to the specific therapeutic indication for enhanced RNA delivery?